Umbilical cord blood stem cell transplantation:
The first successful umbilical cord blood stem cell transplantation was performed in 1988 in Paris, France. The patient was a boy with Fanconi anemia, a genetic and potentially life-threatening form of anemia. Meanwhile, umbilical cord blood stem cell transplants have been successfully performed in patients (mostly children) with about 70 diseases. Umbilical cord blood transplantation (UCBT) has been performed in the clinic for over 30 years.
The umbilical cord of a baby contains blood-forming stem cells, which when transplanted can rebuild the bone marrow and immune system and save the life of a patient with a severe blood disease such as leukaemia, lymphoma or sickle cell disease. The infusion of these cells can also treat patients with inherited genetic disorders, bone marrow failure or inherited immune deficiencies.
UCB is rich in hematopoietic stem cells (HSC), but also contains mesenchymal stem cells, endothelial progenitor cells and other stromal progenitor cells. The biological and immunological properties of umbilical cord blood (UCB) have been investigated and identified in recent years. It has been suggested that the entire mixture of hematopoietic and non-hematopoietic multipotent progenitor cells (and not just a single subpopulation) is important for improving physiological function in certain diseases and brain injuries.
With this cell mixture, other mechanisms than homing and engraftment were investigated, and a therapeutic benefit by paracrine signal transmission was observed. This signal transmission from cell to cell is called paracrine effect. Cord blood can also be used in regenerative medicine. This is due to a combination of additional types of stem cells in the umbilical cord blood, as well as the fact that the cells in the umbilical cord blood release chemical substances that signal the body to heal itself. These chemicals are called cytokines.
Published studies have shown that stem cells from umbilical cord blood help young children with neurological injuries, even if the mechanism of action is not yet fully understood. In other clinical studies, cord blood is used in neurological diseases of adults, including stroke, multiple sclerosis and spinal cord injuries.
Cord blood has been used in clinical trials around the world to treat infants with cerebral palsy, autism, stroke and other brain injuries.